Selected physiological parameters in mouse (0.02kg), rat(0.25kg), rabbit (2.5kg), monkey (5.0kg), dog (10kg) and man (70kg)   -   useful for pharmacokinetic interpretation.
(Data from Davis & Morris, Pharmaceutical Res 10, 1093, 1993)

Organ weights (g)


Mouse

Rat

Rabbit

Monkey

Dog

Human

Brain

0.36

1.8

14

90

80

1400

Liver

1.75

10.0

77

150

320

1800

Kidneys

0.32

2.0

13

25

50

310

Heart

0.08

1.0

5

18.5

80

330

Spleen

0.1

0.75

1

8

25

180

Adrenals

0.004

0.05

0.5

1.2

1

14

Lung

0.12

1.5

18

33

100

1000

Volumes(ml)


Mouse

Rat

Rabbit

Monkey

Dog

Human

Total body water

14.5

167

1790

3465

6036

42000

Intracellular fluid

-

92.8

1165

2425

3276

23800

Extracellular fluid

-

74.2

625

1040

2760

18200

Plasma volume

1.0

7.8

110

224

515

3000

Blood Flow (ml/min)


Mouse

Rat

Rabbit

Monkey

Dog

Human

Brain

-

1.3

-

72

45

700

Liver

1.8

13.8

177

218

309

1450

Kidneys

1.3

9.2

80

138

216

1240

Heart

0.28

3.9

16

60

54

240

Spleen

0.09

0.63

9

21

25

77

Gut

1.5

7.5

111

125

216

1100

Muscle

0.91

7.5

155

90

250

750

Adipose

-

0.4

32

20

35

260

Skin

0.41

5.8

-

54

100

300

Hepatic artery

0.35

2.0

37

51

79

300

Portal vein

1.45

9.8

140

167

230

1150

Cardiac output

8.0

74.0

530

1086

1200

5600

Other fluid flows


Mouse

Rat

Rabbit

Monkey

Dog

Human

Urine flow (ml/day)

1.0

50.0

150

375

300

1400

Bile flow (ml/day)

2.0

22.5

300

125

120

350

GFR (ml/min)

0.28

1.31

7.8

10.4

61.3

125

Miscellaneous parameters


Mouse

Rat

Rabbit

Monkey

Dog

Human

Surface area (m2)

0.008

0.023

0.17

0.32

0.51

1.85

Mean life span (y)

2.7

4.7

8.0

22

20

93

Total plasma protein (g/100ml)

6.2

6.7

5.7

8.8

9.0

7.4

Plasma albumin (g/100 ml)

3.27

3.16

3.87

4.93

2.63

4.18

Plasma α-1-AGP (g/100ml)

1.25

1.81

0.13

0.24

0.37

0.18

Hematocrit (%)

45

46

36

41

42

44

Total ventilation (l/min)

0.025

0.12

0.80

1.67

1.50

7.98

Respiratory rate (min-1)

163

85

51

38

23

12

Heart rate (beats/min)

624

362

213

192

96

65

Oxygen consumption
(ml/h/gbody wt)

1.59

0.84

0.48

0.43

0.34

0.20