Selected physiological parameters in mouse (0.02kg), rat(0.25kg), rabbit (2.5kg), monkey (5.0kg), dog (10kg) and man (70kg) - useful for pharmacokinetic interpretation.
(Data from Davies & Morris, Pharmaceutical Res 10, 1093, 1993)
Organ weights (g)
|
|
Mouse |
Rat |
Rabbit |
Monkey |
Dog |
Human |
|
Brain |
0.36 |
1.8 |
14 |
90 |
80 |
1400 |
|
Liver |
1.75 |
10.0 |
77 |
150 |
320 |
1800 |
|
Kidneys |
0.32 |
2.0 |
13 |
25 |
50 |
310 |
|
Heart |
0.08 |
1.0 |
5 |
18.5 |
80 |
330 |
|
Spleen |
0.1 |
0.75 |
1 |
8 |
25 |
180 |
|
Adrenals |
0.004 |
0.05 |
0.5 |
1.2 |
1 |
14 |
|
Lung |
0.12 |
1.5 |
18 |
33 |
100 |
1000 |
Volumes(ml)
|
|
Mouse |
Rat |
Rabbit |
Monkey |
Dog |
Human |
|
Total body water |
14.5 |
167 |
1790 |
3465 |
6036 |
42000 |
|
Intracellular fluid |
- |
92.8 |
1165 |
2425 |
3276 |
23800 |
|
Extracellular fluid |
- |
74.2 |
625 |
1040 |
2760 |
18200 |
|
Plasma volume |
1.0 |
7.8 |
110 |
224 |
515 |
3000 |
Blood Flow (ml/min)
|
|
Mouse |
Rat |
Rabbit |
Monkey |
Dog |
Human |
|
Brain |
- |
1.3 |
- |
72 |
45 |
700 |
|
Liver |
1.8 |
13.8 |
177 |
218 |
309 |
1450 |
|
Kidneys |
1.3 |
9.2 |
80 |
138 |
216 |
1240 |
|
Heart |
0.28 |
3.9 |
16 |
60 |
54 |
240 |
|
Spleen |
0.09 |
0.63 |
9 |
21 |
25 |
77 |
|
Gut |
1.5 |
7.5 |
111 |
125 |
216 |
1100 |
|
Muscle |
0.91 |
7.5 |
155 |
90 |
250 |
750 |
|
Adipose |
- |
0.4 |
32 |
20 |
35 |
260 |
|
Skin |
0.41 |
5.8 |
- |
54 |
100 |
300 |
|
Hepatic artery |
0.35 |
2.0 |
37 |
51 |
79 |
300 |
|
Portal vein |
1.45 |
9.8 |
140 |
167 |
230 |
1150 |
|
Cardiac output |
8.0 |
74.0 |
530 |
1086 |
1200 |
5600 |
Other fluid flows
|
|
Mouse |
Rat |
Rabbit |
Monkey |
Dog |
Human |
|
Urine flow (ml/day) |
1.0 |
50.0 |
150 |
375 |
300 |
1400 |
|
Bile flow (ml/day) |
2.0 |
22.5 |
300 |
125 |
120 |
350 |
|
GFR (ml/min) |
0.28 |
1.31 |
7.8 |
10.4 |
61.3 |
125 |
Miscellaneous parameters
|
|
Mouse |
Rat |
Rabbit |
Monkey |
Dog |
Human |
|
Surface area (m2) |
0.008 |
0.023 |
0.17 |
0.32 |
0.51 |
1.85 |
|
Mean life span (y) |
2.7 |
4.7 |
8.0 |
22 |
20 |
93 |
|
Total plasma protein (g/100ml) |
6.2 |
6.7 |
5.7 |
8.8 |
9.0 |
7.4 |
|
Plasma albumin (g/100 ml) |
3.27 |
3.16 |
3.87 |
4.93 |
2.63 |
4.18 |
|
Plasma α-1-AGP (g/100ml) |
1.25 |
1.81 |
0.13 |
0.24 |
0.37 |
0.18 |
|
Hematocrit (%) |
45 |
46 |
36 |
41 |
42 |
44 |
|
Total ventilation (l/min) |
0.025 |
0.12 |
0.80 |
1.67 |
1.50 |
7.98 |
|
Respiratory rate (min-1) |
163 |
85 |
51 |
38 |
23 |
12 |
|
Heart rate (beats/min) |
624 |
362 |
213 |
192 |
96 |
65 |
|
Oxygen consumption
(ml/h/gbody wt) |
1.59 |
0.84 |
0.48 |
0.43 |
0.34 |
0.20 |