• I have the most potent compounds in vitro but why do none seem to work in vivo?
• Why is the bioavailability always so low?
• Which in vitro assays best predict in vivo pharmacokinetics?
• Why is there is no relationship between dose and effect?
• How can I get into human without having to produce kilos of bulk drug (API)?
• Which drug-drug interaction studies do I need to do?
• How can I quickly tell if the target works in human?
• What is the quickest way of getting to the right clinical dose?
• What data packages do pharma companies want from their due diligences?
• Are we making the best use of all this pharmacokinetic and pharmacodynamic data?
• There must be a way of speeding the discovery and development of new drugs?